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Dynamic changes in β-cell electrical activity and [Ca <sup>2+</sup> ] regulates NFATc3 activation and downstream gene transcription

2020-06-29

Abstract excerpt

Diabetes results from insufficient insulin secretion as a result of dysfunction to β-cells within the islet of Langerhans. Elevated glucose causes β-cell membrane depolarization and action potential generation, voltage gated Ca 2+ channel activation and oscillations in free-Ca 2+ activity ([Ca 2+ ]), triggering insulin release. Nuclear Factor of Activated T-cell (NFAT) is a transcription factor that is regulate...

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Literature Corpus work
1f13fbbb-7065-5654-9736-8d9da92e9f49
DOI
10.1101/2020.06.28.176768
Open publication

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