Article

Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

2023-10-06

Abstract excerpt

<h4>Background</h4> Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomarker abnormalities and brain atrophy, and is associated with conversion from mild cognitive impairment (MCI) to AD. However, the AD PRS has been examined mainly in Europe...

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Literature Corpus work: 186c4842-54ab-5dc3-9901-6d5261b20713
DOI: 10.1101/2023.10.06.23296656

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