Article

Population-specific polygenic risk for Alzheimer’s disease is associated with Mini-Mental State Examination-based cognitive decline in a Japanese cohort

2026-03-28

Abstract excerpt

Alzheimer’s disease (AD) is a major cause of dementia, with polygenic risk scores (PRSs) widely used to capture cumulative genetic risk. While PRSs have been associated with cognitive decline, their relevance to clinically accessible measures in general populations is not yet fully established, particularly in non-European cohorts. In this study, we investigated the association between AD PRSs and cognitive functi...

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Literature Corpus work: 1257b519-963a-5014-ba89-7884c62c8149
DOI: 10.64898/2026.03.26.26349120

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Population-specific polygenic risk for Alzheimer’s disease is associated with Mini-Mental State Examination-based cognitive decline in a Japanese cohortDOI 10.64898/2026.03.26.26349120Read

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