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Article

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment.

Translational neurodegeneration - 31 Aug 2021

Pyun Jung-Min, Park Young Ho, Lee Keon-Joo, Kim SangYun, Saykin Andrew J, Nho Kwangsik

Abstract excerpt

BACKGROUND: The combinatorial effect of multiple genetic factors calculated as a polygenic risk score (PRS) has been studied to predict disease progression to Alzheimer's disease (AD) from mild cognitive impairment (MCI). Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding...

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Identifiers

PMID: 34465370
DOI: 10.1186/s40035-021-00259-w
PMCID: PMC8406896

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