Article

Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

2023-09-14

Abstract excerpt

<h4>Introduction</h4> Mutations in the Leucine Rich Repeat Kinase 2 ( LRRK2 ) gene cause autosomal dominant Parkinson’s disease (PD) with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human brain and also in the periphery, and high expression of dominant PD genes in immune cells suggest involvement of microglia and macrophages in i...

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Literature Corpus work: 204d135f-f02e-5633-9fbf-a1a650272a06
DOI: 10.1101/2023.09.14.557532

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