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Article

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.

Neurobiology of aging - 1 Oct 2011

Mutez Eugénie, Larvor Lydie, Leprêtre Frédéric, Mouroux Vincent, Hamalek Dorota, Kerckaert Jean-Pierre, Pérez-Tur Jordi, Waucquier Nawal, Vanbesien-Mailliot Christel, Duflot Aurélie, Devos David, Defebvre Luc, Kreisler Alexandre, Frigard Bernard, Destée Alain, Chartier-Harlin Marie-Christine

Abstract excerpt

To gain insight into systemic molecular events associated with an age-related neurodegenerative disorder, we compared gene expression patterns in peripheral blood mononuclear cells (PBMCs) sampled from elderly, healthy controls and from Parkinson's disease (PD) patients carrying the most frequently found mutation of the LRRK2 gene (G2019S). A transcriptomic approach enabled us to detect differentially expressed...

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Identifiers

PMID: 20096956
DOI: 10.1016/j.neurobiolaging.2009.10.016

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