Article

Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells

2023-03-28

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a eukaryotic RNA degradation pathway that targets for degradation faulty mRNAs with premature termination codons as well as many physiological mRNAs encoding full-length proteins. Consequently, NMD functions in both, quality control and post-transcriptional regulation of gene expression, and it has been implicated in the modulation of cancer progression. To investigate the rol...

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Literature Corpus work: 181e34ea-4d2d-589f-ba22-88d4517ad661
DOI: 10.1101/2023.03.28.534516

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