Article

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

2021-03-19

Abstract excerpt

Nonsense-mediated RNA decay (NMD) is well recognized as an RNA surveillance pathway that targets aberrant mRNAs with premature translation termination codons (PTCs) for degradation; however, its molecular mechanisms and roles in health and disease remain incompletely understood. In this study, we developed a novel reporter system that can accurately measure NMD activity in individual cells. By carrying out a genom...

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Literature Corpus work: 9f2a2b1c-5e01-5a3d-a3dc-11183f1602f1
DOI: 10.1101/2021.03.19.436079

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