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Article

Deciphering the nonsense-mediated mRNA decay pathway to identify cancer cell vulnerabilities for effective cancer therapy.

Journal of experimental & clinical cancer research : CR - 1 Dec 2021

Bongiorno Roberta, Colombo Mario Paolo, Lecis Daniele

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a highly conserved cellular surveillance mechanism, commonly studied for its role in mRNA quality control because of its capacity of degrading mutated mRNAs that would produce truncated proteins. However, recent studies have proven that NMD hides more complex tasks involved in a plethora of cellular activities. Indeed, it can control the stability of mutated as well as...

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PMID: 34852841
DOI: 10.1186/s13046-021-02192-2
PMCID: PMC8638473

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