Article
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America - 10 Sept 2013
Usuki Fusako, Yamashita Akio, Shiraishi Tadafumi, Shiga Atsushi, Onodera Osamu, Higuchi Itsuro, Ohno Shigeo
Abstract excerpt
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits the production of aberrant proteins that still retain, at least in part, wild-type function as well as dominant-negative peptides. Therefore, the selective inhibition of NMD has the potential to ameliorate NMD-exacerbated mutant phenotypes. However, we do...
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