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Article

Nonsense-mediated mRNA Decay and Cancer.

Current opinion in genetics & development - 1 Feb 2018

Popp Maximilian W, Maquat Lynne E

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key tumor-suppressor mRNAs. In other cases, tumors adjust NMD...

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Identifiers

PMID: 29121514
DOI: 10.1016/j.gde.2017.10.007
PMCID: PMC5869107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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