Article
Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations.
Cancer research - 1 Sept 2021
Cheruiyot Abigael, Li Shan, Nonavinkere Srivatsan Sridhar, Ahmed Tanzir, Chen Yuhao, Lemacon Delphine S, Li Ying, Yang Zheng, Wadugu Brian A, Warner Wayne A, Pruett-Miller Shondra M, Obeng Esther A, Link Daniel C, He Dalin, Xiao Fei, Wang Xiaowei, Bailis Julie M, Walter Matthew J, You Zhongsheng
Abstract excerpt
Nonsense-mediated RNA decay (NMD) is recognized as an RNA surveillance pathway that targets aberrant mRNAs with premature translation termination codons (PTC) for degradation, however, its molecular mechanisms and roles in health and disease remain incompletely understood. In this study, we developed a novel reporter system to accurately measure NMD activity in individual cells. A genome-wide CRISPR-Cas9 knockout...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.