Article

Natural killer cell dysfunction drives keloid pathogenesis

2024-11-22

Abstract excerpt

<h4>Summary</h4> Keloids, characterized by excessive scar tissue resulting from abnormal wound healing, are primarily driven by hyperproliferative fibroblasts and overproduction of extracellular matrix. Although human natural killer (NK) cells are known for their role in inhibiting uncontrolled cell growth through cytokines like IFN-γ and TNF-α, they also produce amphiregulin (AREG), which paradoxically promotes...

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Literature Corpus work: 88e13e78-9e82-51a0-b238-d1d52af52abd
DOI: 10.1101/2024.11.20.624588

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