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Dysfunctional natural killer cells can be reprogrammed to regain anti-tumor activity

18 Apr 2024

Abstract excerpt

Natural killer (NK) cells are critical to the innate immune system, as they recognize antigens without prior sensitization, and contribute to the control and clearance of viral infections and cancer. However, a significant proportion of NK cells in mice and humans do not express classical inhibitory receptors during their education process and are rendered naturally "anergic", i.e., exhibiting reduced effector...

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PMID: 38637625
DOI: 10.1038/s44318-024-00094-5

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