Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-γ secretion by natural killer cells

1 Sept 2022

Abstract excerpt

Natural killer (NK) cells are lymphocytes that are involved in controlling tumors or microbial infections through the production of interferon gamma (IFN-γ). Granulocyte colony-stimulating factor (G-CSF) inhibits IFN-γ secretion by NK cells, but the mechanism underlying this effect remains unclear. Here, by comparing the multi-omics profiles of human NK cells before and after in vivo G-CSF treatment, we identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Cell Function and Interaction
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36103837
DOI: 10.1016/j.celrep.2022.111342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo G-CSF treatment activates the GR-SOCS1 axis to suppress IFN-γ secretion by natural killer cellsPMID 36103837Read ↗

Glucocorticoid receptor activation reprograms NK cells to drive AREG-mediated immunosuppression in skin cancerSemantic proximity Read ↗

Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)Semantic proximity Read ↗

Implications of a 'Third Signal' in NK Cells.Semantic proximity Read ↗

Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients.Semantic proximity Read ↗

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammationSemantic proximity Read ↗

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritisSemantic proximity Read ↗

Glucocorticoid modulation of cytokine signalingSemantic proximity Read ↗

Development of novel treatment strategies for inflammatory diseases—similarities and divergence between glucocorticoids and GILZSemantic proximity Read ↗

ADSC secretome constrains NK cell activity by attenuating IL-2–mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4Semantic proximity Read ↗

Minireview: Glucocorticoids in Autoimmunity: Unexpected Targets and MechanismsSemantic proximity Read ↗

Glucocorticoid Synergistically Activate Stat3 and NF-κB with Inflammatory Cytokines and Enhance the Anti-inflammatory Function of Mesenchymal Stem/Stromal CellsSemantic proximity Read ↗

The Type I Interferon Signaling Pathway Is a Target for Glucocorticoid InhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.