Article

Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activities

2026-04-22

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor p63 is critical for epithelial development and implicated in tumorigenesis. However, our understanding of the role of p63 in development and disease has been complicated by its diverse isoforms. As a member of the p53 family member of genes, TP63 encodes for numerous isoforms, including the N-terminal variants TAp63 and ΔNp63, which are generated through alternative pro...

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Literature Corpus work: 17efe469-72ac-5d96-8f2d-303a017e2814
DOI: 10.64898/2026.04.19.719484

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