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p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer

3 Jan 2025

Abstract excerpt

The p63 protein is a master regulatory transcription factor that plays crucial roles in cell differentiation, adult tissue homeostasis, and chromatin remodeling, and its dysregulation is associated with genetic disorders, physiological and premature aging, and cancer. The effects of p63 are carried out by two main isoforms that regulate cell proliferation and senescence. p63 also controls the epigenome by...

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PMID: 39791744
DOI: 10.3390/cells14010043

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