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Article

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.

Cancer research - 15 Jan 2018

Abbas Hussein A, Bui Ngoc Hoang Bao, Rajapakshe Kimal, Wong Justin, Gunaratne Preethi, Tsai Kenneth Y, Coarfa Cristian, Flores Elsa R

Abstract excerpt

TP63 is required to maintain stem cell pluripotency and suppresses the metastatic potential of cancer cells through multiple mechanisms. These functions are differentially regulated by individual isoforms, necessitating a deeper understanding of how the distinct transcriptional programs controlled by these isoforms affect cancer progression and outcomes. In this study, we conducted a pan-cancer analysis of The...

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Identifiers

PMID: 29180475
DOI: 10.1158/0008-5472.CAN-17-1803
PMCID: PMC5771893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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