Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p53-homologue p63 may promote thyroid cancer progression.

Endocrine-related cancer - 1 Dec 2005

Malaguarnera Roberta, Mandarino Angelo, Mazzon Emanuela, Vella Veronica, Gangemi Piero, Vancheri Carlo, Vigneri Paolo, Aloisi Alessandra, Vigneri Riccardo, Frasca Francesco

Abstract excerpt

Inactivation of p53 and p73 is known to promote thyroid cancer progression. We now describe p63 expression and function in human thyroid cancer. TAp63alpha is expressed in most thyroid cancer specimens and cell lines, but not in normal thyrocytes. However, in thyroid cancer cells TAp63alpha fails to induce the target genes (p21Cip1, Bax, MDM2) and, as a consequence, cell cycle arrest and apoptosis occur....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to Protein Isoforms

Share to Thyroid Gland

Share to Thyroid Neoplasms

Share to Trans-Activators

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 16322335
DOI: 10.1677/erc.1.00968

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p53-homologue p63 may promote thyroid cancer progression.PMID 16322335Read ↗

The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemSemantic proximity Read ↗

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancersSemantic proximity Read ↗

TP53 family members and human cancers.Semantic proximity Read ↗

Isoform-specific cofactor recruitment through the intrinsically disordered N-terminus of p63 underlies differential transcriptional activitiesSemantic proximity Read ↗

p63-related signaling at a glanceSemantic proximity Read ↗

Role of p53 family members p73 and p63 in human hematological malignanciesSemantic proximity Read ↗

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein DegradationSemantic proximity Read ↗

p73 tumor-suppressor activity is impaired in human thyroid cancer.Semantic proximity Read ↗

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissuesSemantic proximity Read ↗

The diverse oncogenic and tumour suppressor roles of p63 and p73 in cancer: a review by cancer site.Semantic proximity Read ↗

TAp63 and DeltaNp63 in cancer and epidermal development.Semantic proximity Read ↗

New Insights in Thyroid Cancer and p53 Family Proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.