Article
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.
Molecular and cellular biology - 1 Dec 2002
Serber Zach, Lai Helen C, Yang Annie, Ou Horng D, Sigal Martina S, Kelly Alexander E, Darimont Beatrice D, Duijf Pascal H G, Van Bokhoven Hans, McKeon Frank, Dötsch Volker
Abstract excerpt
The human genome is far smaller than originally estimated, and one explanation is that alternative splicing creates greater proteomic complexity than a simple count of open reading frames would suggest. The p53 homologue p63, for example, is a tetrameric transcription factor implicated in epithelial development and expressed as at least six isoforms with widely differing transactivation potential. In particular,...
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