Article
p63 and p73 in human cancer: defining the network.
Oncogene - 9 Aug 2007
Deyoung M P, Ellisen L W
Abstract excerpt
The p53-related genes p63 and p73 exhibit significant structural homology to p53; however, they do not function as classical tumor suppressors and are rarely mutated in human cancers. Both p63 and p73 exhibit tissue-specific roles in normal development and a complex contribution to tumorigenesis that is due to their expression as multiple protein isoforms. The predominant p63/p73 isoforms expressed both in normal...
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