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A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues

6 Aug 2015

Abstract excerpt

BACKGROUND: The transcription factor p63 belongs to the p53/p63/p73 family and plays key functional roles during normal epithelial development and differentiation and in pathological states such as squamous cell carcinomas. The human TP63 gene, located on chromosome 3q28 is driven by two promoters that generate the full-length transactivating (TA) and N-terminal truncated (ΔN) isoforms. Furthermore alternative...

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PMID: 26251276
DOI: 10.1186/s12864-015-1793-9

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