Article

Differential transcriptional activity of ΔNp63β is encoded by an isoform-specific C-terminus

2024-12-03

Abstract excerpt

<h4>ABSTRACT</h4> p63 is a clinically-relevant transcription factor heavily involved in development and disease. Mutations in the p63 DNA-binding domain lead to severe developmental defects and overexpression of p63 plays a role in the progression of epithelial-associated cancers. Unraveling the specific biochemical mechanisms underlying these phenotypes is made challenging by the presence of multiple p63 isoform...

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Literature Corpus work: d693faf1-7f04-54f0-b088-ad6566592697
DOI: 10.1101/2024.12.03.626646

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