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Article

DNA-Binding and Transactivation Activities Are Essential for TAp63 Protein Degradation

30 Jun 2005

Abstract excerpt

The p53-related p63 gene encodes six isoforms with differing N and C termini. TAp63 isoforms possess a transactivation domain at the N terminus and are able to transactivate a set of genes, including some targets downstream of p53. Accumulating evidence indicates that TAp63 plays an important role in regulation of cell proliferation, differentiation, and apoptosis, whereas transactivation-inert deltaNp63...

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Identifiers

PMID: 15988026
DOI: 10.1128/mcb.25.14.6154-6164.2005

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