Article

A diffusion-like process enables expansion of advantaged gene mutations in human colonic epithelium

2020-07-12

Abstract excerpt

Colorectal cancer is thought to arise when the mutational burden of the clonal population of stem cells within a colonic crypt exceeds a certain threshold. Therefore, quantification of the fixation and subsequent expansion of somatic mutations in histologically normal epithelium is key to understanding colorectal cancer initiation. Here, using immunohistochemistry, loss of the histone demethylase KDM6A in normal h...

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Literature Corpus work: c79ee757-8fc3-5b7b-83c3-4b879a325fbf
DOI: 10.1101/2020.07.10.193748

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