Investigating the fixation and spread of mutations in the gastrointestinal epithelium.

doi:10.2217/14796694.4.6.825

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Article

Investigating the fixation and spread of mutations in the gastrointestinal epithelium.

Future oncology (London, England) - 1 Dec 2008

Graham Trevor A, Wright Nicholas A

Abstract excerpt

Tissue-specific stem cells are responsible for the maintenance of the epithelium throughout the gastrointestinal tract. The accumulation of mutations in these stem cells is the likely cause of most gastrointestinal cancers. Clonal analysis of these stem cell populations has revealed how normal homeostatic processes work and how neoplastic growth occurs. In this review, we consider the clonal dynamics of stem...

Topics

Animals
Cell Transformation, Neoplastic
Clone Cells
Gastric Mucosa
Gastrointestinal Neoplasms
Humans
Intestinal Mucosa
Mutation
Neoplastic Stem Cells

Source

Open in PubMed

Identifiers

PMID: 19086849
DOI: 10.2217/14796694.4.6.825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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