Article
Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.
Nature communications - 9 Jun 2026
Agrawal Parul, Feng Junli, Kallur Siddaramaiah Latha, Khechaduri Arineh, Salladay Kelsey R, Hinton Karli, Means Madison, Rose Julianna A, Cohen Luziana, Tian Ming, Baboo Sabyasachi, Diedrich Jolene K, Reese Todd, Kara Derin, Yates John R, Paulson James C, Alt Frederick W, Pancera Marie, Stamatatos Leonidas
Abstract excerpt
VRC01-class HIV broadly neutralizing antibodies have been isolated from people living with HIV. Their unmutated (germline) forms do not bind Env and do not neutralize HIV. They acquire their broadly neutralizing potentials through the accumulation of specific somatic mutations. Here, we identify key modifications that allow Env-derived proteins from diverse HIV clades to effectively engage germline VRC01-class B...
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