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Article

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.

Immunity - 9 Feb 2021

Chen Xuejun, Zhou Tongqing, Schmidt Stephen D, Duan Hongying, Cheng Cheng, Chuang Gwo-Yu, Gu Ying, Louder Mark K, Lin Bob C, Shen Chen-Hsiang, Sheng Zizhang, Zheng Michelle X, Doria-Rose Nicole A, Joyce M Gordon, Shapiro Lawrence, Tian Ming, Alt Frederick W, Kwong Peter D, Mascola John R

Abstract excerpt

Vaccine elicitation of broadly neutralizing antibodies (bnAbs) is a key HIV-research goal. The VRC01 class of bnAbs targets the CD4-binding site on the HIV-envelope trimer and requires extensive somatic hypermutation (SHM) to neutralize effectively. Despite substantial progress, vaccine-induced VRC01-class antibodies starting from unmutated precursors have exhibited limited neutralization breadth, particularly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33453152
DOI: 10.1016/j.immuni.2020.12.014
PMCID: PMC8020832

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