Article

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

2022-09-12

Abstract excerpt

<h4>Summary</h4> Passive transfer of broadly neutralizing anti-HIV-1 antibodies (bNAbs) protects against infection, and therefore eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4-binding site (CD4bs) on HIV-1 Env are among the most broadly active, but to date, responses elicited against this epitope in vaccinated animals have lacked potency and breadth. We hypothe...

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Literature Corpus work: 7e3ecc5c-391f-5466-aab8-e5869ff9b299
DOI: 10.1101/2022.09.08.507086

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