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Article

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

2025-01-17

Abstract excerpt

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that thousands of hominoid-specific L1 integrants are expressed in human i...

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Identifiers and source

Literature Corpus work
176c8366-ae21-583b-991c-bc2383418b7e
DOI
10.1101/2025.01.17.633315
Open publication

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LINE-1 retrotransposons regulate the exit of human pluripotency and early brain developmentDOI 10.1101/2025.01.17.633315
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