Article

Structurally conserved primate lncRNAs are transiently expressed during human cortical differentiation and influence cell type specific genes

2017-12-12

Abstract excerpt

<h4>SUMMARY</h4> The cerebral cortex has expanded in size and complexity in primates, yet the underlying molecular mechanisms are obscure. We generated cortical organoids from human, chimpanzee, orangutan, and rhesus pluripotent stem cells and sequenced their transcriptomes at weekly time points for comparative analysis. We used transcript structure and expression conservation to discover thousands of expressed l...

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Literature Corpus work: ebadad7b-baea-5a48-99d7-eac00aa7f336
DOI: 10.1101/232553

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