Article

L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification

2023-03-06

Abstract excerpt

The genetic mechanisms underlying the expansion in size and complexity of the human brain remains poorly understood. L1 retrotransposons are a source of divergent genetic information in hominoid genomes, but their importance in physiological functions and their contribution to human brain evolution is largely unknown. Using multi-omic profiling we here demonstrate that L1-promoters are dynamically active in the de...

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Literature Corpus work: 7f11db25-eeda-5ac7-91b0-72decfb422d1
DOI: 10.1101/2023.03.04.531072

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