Article

A human-specific regulatory mechanism revealed in a preimplantation model

2025-05-12

Abstract excerpt

Stem cell-based human embryo models offer a unique opportunity for functional studies of the human-specific features of development. Here, we genetically and epigenetically manipulate human blastoids, a 3D embryo model of the blastocyst, to investigate the functional impact of HERVK LTR5Hs, a hominoid-specific endogenous retrovirus, on preimplantation development. We uncover a pervasive cis-regulatory contribution...

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Literature Corpus work: 1d43565a-7e87-59fb-a8d2-aa195f8549a5
DOI: 10.1101/2025.05.10.653263

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