Article

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis

2023-05-12

Abstract excerpt

ATGL is the key enzyme in intracellular lipolysis playing a critical role in metabolic and cardiovascular diseases. ATGL is tightly regulated through a known set of protein-protein interaction partners with activating or inhibiting functions in control of lipolysis. However, the binding mode and protein interaction sites of ATGL and its partners are unknown. Using deep mutational protein interaction perturbation s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 17579b35-abc4-5c98-9695-75a9ac8bf56a
DOI: 10.1101/2023.05.10.540188

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysisDOI 10.1101/2023.05.10.540188Read

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.Semantic proximity Read

Molecular Basis of ABHD5 Lipolysis Activation.Semantic proximity Read

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosisSemantic proximity Read

Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.Semantic proximity Read

Decoding ATG9A Variation: A Comprehensive Structural Investigation of All Missense VariantsSemantic proximity Read

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.Semantic proximity Read

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance PathwaysSemantic proximity Read

Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.Semantic proximity Read

Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator.Semantic proximity Read

Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities.Semantic proximity Read

The lipin family: mutations and metabolism.Semantic proximity Read

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read