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Article

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.

Nature communications - 21 Mar 2024

Kohlmayr Johanna M, Grabner Gernot F, Nusser Anna, Höll Anna, Manojlović Verina, Halwachs Bettina, Masser Sarah, Jany-Luig Evelyne, Engelke Hanna, Zimmermann Robert, Stelzl Ulrich

Abstract excerpt

ATGL is a key enzyme in intracellular lipolysis and plays an important role in metabolic and cardiovascular diseases. ATGL is tightly regulated by a known set of protein-protein interaction partners with activating or inhibiting functions in the control of lipolysis. Here, we use deep mutational protein interaction perturbation scanning and generate comprehensive profiles of single amino acid variants that affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38514628
DOI: 10.1038/s41467-024-46937-x
PMCID: PMC10958042

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