Article

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance Pathways

2024-11-03

Abstract excerpt

A common variant of PNPLA3 , encoding PNPLA3-I148M, is the most significant genetic determinant of fatty liver disease worldwide. However, it is unclear precisely how PNPLA3-I148M drives disease risk. Here, we show that endogenous human PNPLA3-I148M impairs secretion of Apolipoprotein B (ApoB), the scaffolding protein of very low-density lipoproteins (VLDLs), from hepatocytes. This is not due to a generalized sec...

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Literature Corpus work: 0561abba-d665-5af7-ad67-21bc826994f2
DOI: 10.1101/2024.10.29.620978

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