Article

Decoding ATG9A Variation: A Comprehensive Structural Investigation of All Missense Variants

2026-02-05

Abstract excerpt

Macroautophagy (hereafter autophagy) is a cellular recycling pathway that requires different ATG (autophagy-related) proteins to generate double-membraned autophagosomes. ATG9A, a multi-spanning membrane protein, plays a crucial role in this process as the only transmembrane component of the core autophagy machinery. ATG9A functions as a lipid scramblase, redistributing lipids between membrane leaflets for the exp...

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Literature Corpus work: a98e9d26-c05f-5e5d-a2e2-c04f84946f55
DOI: 10.64898/2026.02.03.703515

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