Article

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis

2024-10-03

Abstract excerpt

The storage and release of triacylglycerol (TAG) in lipid droplets (LDs) is regulated by dynamic protein interactions. α/β hydrolase domain-containing protein 5 (ABHD5; also known as CGI-58) is a membrane/LD bound protein that functions as a co-activator of Patatin Like Phospholipase Domain Containing 2 (PNPLA2; also known as Adipose triglyceride lipase, ATGL) the rate-limiting enzyme for TAG hydrolysis. The dysre...

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Literature Corpus work: 38cfe342-16c1-5667-8455-5d1e57cfb8c7
DOI: 10.1101/2024.10.03.616525

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