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Article

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.

Cell metabolism - 1 May 2006

Yen Chi-Liang Eric, Farese Robert V

Abstract excerpt

The hydrolysis of fat stored in adipose tissues is crucial for providing energy during fasting and exercise, and dysregulation of fat breakdown may contribute to metabolic disease. In this issue of Cell Metabolism, report that CGI-58/ABHD5, a lipid-droplet-associated protein that is mutated in a rare disease characterized by excess lipid storage, activates adipose triglyceride lipase and thus may regulate fat...

Read the complete abstract on PubMed

Topics

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Share to 1-Acylglycerol-3-Phosphate O-Acyltransferase
Share to Adipose Tissue
Share to Esterases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipase

Share to Lipid Metabolism, Inborn Errors

Share to Lipolysis

Share to Phospholipases A

Share to Triglycerides

Source

Identifiers

PMID: 16679288
DOI: 10.1016/j.cmet.2006.04.001

Genes

ABHD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.PMID 16679288Read ↗

Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase.Semantic proximity Read ↗

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5.Semantic proximity Read ↗

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosisSemantic proximity Read ↗

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Molecular Basis of ABHD5 Lipolysis Activation.Semantic proximity Read ↗

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Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.Semantic proximity Read ↗

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Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores.Semantic proximity Read ↗

PNPLA3-I148M is a Neomorph that Interferes with Two Primary Hepatic Triglyceride Clearance PathwaysSemantic proximity Read ↗

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