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Article

Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator.

Scientific reports - 16 Feb 2022

Tseng Yan Yuan, Sanders Matthew A, Zhang Huamei, Zhou Li, Chou Chia-Yi, Granneman James G

Abstract excerpt

Alpha/beta hydrolase domain-containing protein 5 (ABHD5) is a highly conserved protein that regulates various lipid metabolic pathways via interactions with members of the perilipin (PLIN) and Patatin-like phospholipase domain-containing protein (PNPLA) protein families. Loss of function mutations in ABHD5 result in Chanarin-Dorfman Syndrome (CDS), characterized by ectopic lipid accumulation in numerous cell...

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Share to 1-Acylglycerol-3-Phosphate O-Acyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35173175
DOI: 10.1038/s41598-021-04179-7
PMCID: PMC8850477

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