The lipin family: mutations and metabolism.

doi:10.1097/MOL.0b013e32832adee5

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Article

The lipin family: mutations and metabolism.

Current opinion in lipidology - 1 Jun 2009

Reue Karen

Abstract excerpt

PURPOSE OF REVIEW: The family of three lipin proteins act as phosphatidate phosphatase (PAP) enzymes required for glycerolipid biosynthesis, and also as transcriptional coactivators that regulate expression of lipid metabolism genes. The genes for lipin-1, lipin-2 and lipin-3 are expressed in key metabolic tissues, including adipose tissue, skeletal muscle and liver, but the physiological functions of each member...

Topics

Animals
Disease
Gene Expression Regulation
Humans
Mutation
Nuclear Proteins
Polymorphism, Genetic

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