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Article

Molecular Basis of ABHD5 Lipolysis Activation.

Scientific reports - 17 Feb 2017

Sanders Matthew A, Zhang Huamei, Mladenovic Ljiljana, Tseng Yan Yuan, Granneman James G

Abstract excerpt

Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lipase (ATGL)-mediated lipolysis that plays important roles in metabolism, tumor progression, viral replication, and skin barrier formation. The structural determinants of ABHD5 lipolysis activation, however, are unknown. We performed comparative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28211464
DOI: 10.1038/srep42589
PMCID: PMC5314347

Genes

ABHD5
ABHD4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Basis of ABHD5 Lipolysis Activation.PMID 28211464Read ↗

Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator.Semantic proximity Read ↗

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysisSemantic proximity Read ↗

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.Semantic proximity Read ↗

Lipid Droplet Targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosisSemantic proximity Read ↗

Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.Semantic proximity Read ↗

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chainsSemantic proximity Read ↗

Early onset of Chanarin-Dorfman syndrome with severe liver involvement in a patient with a complex rearrangement of ABHD5 promoter.Semantic proximity Read ↗

Bioinformatics analysis identifies sequence determinants of enzymatic activity for the PHARC associated lipase ABHD12Semantic proximity Read ↗

Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.Semantic proximity Read ↗

PNPLA3(148M) promotes hepatic steatosis by interfering with triglyceride hydrolysis through a gain-of-function mechanismSemantic proximity Read ↗

An exceptional mutational event leading to Chanarin-Dorfman syndrome in a large consanguineous family.Semantic proximity Read ↗

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.Semantic proximity Read ↗

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