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Article

Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.

PloS one - 1 Jan 2013

Murugesan Sricharan, Goldberg Elysa B, Dou Eda, Brown William J

Abstract excerpt

Members of the Patatin-like Phospholipase Domain containing Protein A (PNPLA) family play key roles in triglyceride hydrolysis, energy metabolism, and lipid droplet (LD) homoeostasis. Here we report the identification of two distinct LD targeting motifs (LTM) for PNPLA family members. Transient transfection of truncated versions of human adipose triglyceride lipase (ATGL, also known as PNPLA2),...

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Source

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Identifiers

PMID: 23741432
DOI: 10.1371/journal.pone.0064950
PMCID: PMC3669214

Genes

PNPLA5
PNPLA3
PNPLA2
PNPLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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