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Article

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

1 Jul 2019

Abstract excerpt

The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and proliferation. The canonical AMP-dependent mechanism of activation requires the upstream kinase LKB1, which was identified genetically to be a tumour suppressor. AMPK can...

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PMID: 31288625
DOI: 10.1098/rsob.190099

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