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Article

The AMPK-FoxO3A axis as a target for cancer treatment

15 Mar 2010

Abstract excerpt

FoxO proteins are an evolutionarily conserved subfamily of transcription factors involved in tumor suppression, regulation of energy metabolism and development in several tissues, and are mainly regulated by phosphorylation-dependent nuclear/cytoplasmic shuttling. The transcriptional activity of FoxO3A, one of the four members of the family, is further modulated by AMPK, one of the key regulators of cellular...

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PMID: 20190568
DOI: 10.4161/cc.9.6.11035

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