Article

Investigating the regulation of AMP-activated protein kinase

2018-01-01

Abstract excerpt

AMP-activated protein kinase (AMPK) is a highly evolutionarily conserved heterotrimeric kinase, characterised as a critical sensor of energetic stress. AMPK is being investigated as a therapeutic target for metabolic diseases including type II diabetes, obesity and cancer. The development of direct pharmacological activators has revealed a novel binding site on AMPK, termed the allosteric drug and metabolite (ADaM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 751b4599-66ce-5c39-a198-1da40f8493f8
DOI: 10.25560/78211

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the regulation of AMP-activated protein kinaseDOI 10.25560/78211Read

AMP-activated protein kinase – not just an energy sensorSemantic proximity Read

Investigating the regulation of AMP-activated protein kinase and SNF1Semantic proximity Read

Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation.Semantic proximity Read

Effect of different γ-subunit isoforms on the regulation of AMPK.Semantic proximity Read

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.Semantic proximity Read

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827Semantic proximity Read

AMP-activated protein kinase regulates hERG potassium channel.Semantic proximity Read

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?Semantic proximity Read

Advances in the research of AMPK and its subunit genes.Semantic proximity Read

Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscleSemantic proximity Read

Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.Semantic proximity Read

Role of AMP-activated protein kinase in the metabolic syndrome and in heart disease.Semantic proximity Read