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Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase

1 Apr 2009

Abstract excerpt

Caloric restriction has long been recognized as an extremely effective cancer preventive. Current population demographics suggest that caloric excess and obesity will lead to increased cancer incidence, underscoring the need to elucidate the molecular mechanisms that couple dysregulated energy homeostasis to aberrant cell growth. The AMP-activated protein kinase (AMPK) is a critical monitor of cellular energy...

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PMID: 19336731
DOI: 10.1158/1940-6207.capr-08-0166

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