Article

Type I interferon dynamics determines memory B cell epigenetic identity in chronic viral infection

2023-03-02

Abstract excerpt

<h4>SUMMARY</h4> Memory B cells are key providers of long-lived immunity against infectious disease, yet in chronic viral infection they do not produce effective protection. How chronic viral infection disrupts memory B cell development, and whether such changes are reversible, remains unknown. Here, we uncover type-I interferon (IFN-I) dynamics as a key determinant in shaping chronic memory B cell development. T...

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Literature Corpus work: 16fbd41a-f053-5bf0-951d-dab1e345d467
DOI: 10.1101/2023.03.02.530850

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