Article

Targeting Interferon-Driven Inflammatory Memory Prevents Epigenetic Evolution of Cancer Immunotherapy Resistance

2024-08-16

Abstract excerpt

<h4>SUMMARY</h4> Acquired resistance is a growing obstacle to durable responses after cancer immune checkpoint blockade (ICB). The mechanisms by which heterogeneous tumors evolve under immunotherapy pressure and strategies targeting key populations to prevent relapse are poorly understood. We show that chronic interferon (IFN) enables a subpopulation of cancer cells to acquire inflammatory memory and express memo...

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Literature Corpus work: f792c200-966f-5c87-95a3-de237e2cd8de
DOI: 10.1101/2024.08.13.607862

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