Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS-CoV-2 inflammation durably imprints memory CD4 T cells

21 Jun 2024

Abstract excerpt

Memory CD4 T cells are critical to human immunity, yet it is unclear whether viral inflammation during memory formation has long-term consequences. Here, we compared transcriptional and epigenetic landscapes of Spike (S)-specific memory CD4 T cells in 24 individuals whose first exposure to S was via SARS-CoV-2 infection or mRNA vaccination. Nearly 2 years after memory formation, S-specific CD4 T cells established...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune responses and vaccinations
Share to SARS-CoV-2 and COVID-19 Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38905326
DOI: 10.1126/sciimmunol.adj8526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 inflammation durably imprints memory CD4 T cellsPMID 38905326Read ↗

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunitySemantic proximity Read ↗

Imprinted SARS-CoV-2-Specific Memory Lymphocytes Define Hybrid ImmunitySemantic proximity Read ↗

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells.Semantic proximity Read ↗

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cellsSemantic proximity Read ↗

Mode of T cell priming durably shapes the TCR repertoire, effector function and α4β1 integrin expression of human virus-specific CD4 <sup>+</sup> T cellsSemantic proximity Read ↗

Immune Imprinting and Implications for COVID-19Semantic proximity Read ↗

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infectionSemantic proximity Read ↗

Gene regulatory network determinants of rapid recall in human memory CD4+ T cellsSemantic proximity Read ↗

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19Semantic proximity Read ↗

Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read ↗

mRNA COVID-19 vaccine elicits potent adaptive immune response without the persistent inflammation seen in SARS-CoV-2 infectionSemantic proximity Read ↗

Delineation of a molecularly distinct terminally differentiated memory CD8 T cell populationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.